publications

There are published preclinical studies by both independent researchers as well as by Metro International Biotech founders and advisors in leading scientific and medical journals, establishing the potential of enhanced NAD+ levels for rare mitochondrial, aging-related and more mainstream diseases.

CLINICAL AND preclinical evidence that disease and age-related functional decline can be mitigated by boosting NAD+

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.

MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults.

Supplementation with an NAD precursor delayed motor neuron degeneration, decreased markers of neuroinflammation in the spinal cord increased survival in a mouse model of ALS. (Harlan et al., Exp. Neurology. 2020. 327 (113219): 1-10)

NAD precursor improves blood flow and musculoskeletal endurance in elderly mice (Das et al., Cell. 2018. 173: 1-16)

An NAD precursor reduced Aβ deposits in worms and in the cortex tissues of mice with Alzheimer’s Disease. (Sorrentino et al. Nature. 2017. 552: 187-193)

Replenishing NAD in a mouse model of muscular dystrophy with a dietary precursor improves mitochondrial and muscle function and heart pathology (Ryu et al., Science Translational Medicine 2016. 8 (361): 1-14)

NAD precursor suppresses age-associated body weight gain and improves energy metabolism, physical activity, insulin sensitivity and plasma lipid profile in mice (Mills et al., Cell Metabolism. 2016. 24(6):795-806)

Photoreceptor-specific deletion of a rate-limiting enzyme in the NAD+ biosynthetic pathway causes retinal degeneration. NAD precursor rescues vision (Lin et al., Cell Reports. 2016. 17(1): 69-85)

NAD+ precursor treats mitochondrial myopathy in mice, inducing mitochondrial biogenesis in skeletal muscle and preventing muscle abnormalities (Khan et all, EMBO Mol Med. 2014. 6:721-731)

NAD+ precursor prevents noise-induced hearing loss and spiral ganglia neurite degeneration even after noise exposure (Brown et al., Cell Metabolism. 2014. 20: 1059-1068)